posted
And for those who are interested here is the dime tour,
The core of the theory is that damage/dysfunction of the tight junctions of the blood brain barrier (and other tight junctions such as those surrounding innervation to organs) results in nutrients that are actively transported across the BBB 'leaking out' of the Interstitial Fluid (ISF) back to the blood. This includes many components needed for the synthesis of of key neurotransmitters (particularly L-DOPA/dopamine/epinephrine/norepinephrine the 'dopamine path' and melatonin/serotonin + creatine/adenosine path) mylenation (biotin) and protection/repair of oxidative damage (Glutathione). This results in a biosynthesis path deficiency which is often comorbid with a blood deficiency of the relevant nutrients. The pattern of and intensity of the damage (as well as timing) and degree of deficiency determines the particular neurological disease and pathology encountered.
For many neurological diseases the occurrence of oxidative damage is primarily during fetal development (hypoxia + low glutathione) although often with later developmental damage. Oxidative damage to the tight junctions of the barriers surrounding organ innervation is the reason for comorbid auto immune diseases - and general oxidative damage can result in other diseases comorbidites that will be normally distributed (so you will see seemingly random commordibity with a large number of congenital diseases). Certain events after birth can result in further nutrient deficiency and/or oxidative damage and/or other causes of increased leakiness (ie low blood pressure). Also the demands due to growth will exacerbate deficiencies.
The brain has a compensatory mechanism for low dopamine - cortisol - which tightens the junctions and reduces their leakiness in a global manner, it also stimulates tryptophan catabolism because dopamine path competes with tryptophan path for nutrients and dopamine is more important for survival. This catabolism of tryptophan results in reduction of serotonin production (leading to comorbid depression, anxiety, anger, sleep disorders and numerous other issues related to serotonin path deficiency and increased autoimmune response). The compensation mechanism can result in undamaged areas gaining superior ability (savants, heightened sense or senses - smell, touch, hearing) as these brain areas will have a relative excess neurotransmitter and other nutrient availability to normal.
The results of twin studies are primarily due to shared vs unshared placenta, not genetics (as is clear when we look at dichorionic studies versus monochorionic for the few times they have been done ie for schizophrenia).
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posted
Note that this theory lets us play '7 degrees of kevin bacon' with diseases
For instance Seasonal Affective Disorder
Low sunlight -> low vitamin D -> vitamin D deficient anemia and oxidative damage to tight junctions unrepaired -> low dopamine -> high cortisol -> low tryptophan -> low melatonin (sleep dysregulation) and low serotonin (depression)
Or lets play Post Traumatic Stress Disorder
shockwave from concussion -> trauma to tight junctions -> low dopamine -> high cortisol -> low tryptophan -> low melatonin and low serotonin -> depression/anger/assorted mental disorders depending on where the damage occurred
I can play this game with pretty much any neurological disease and a huge host of diseases without a suspected neuro component.
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posted
Congrats. Isn't self e-publishing awesome? Now if I only knew how to promote my book better...
Posts: 19145 | Registered: Jan 2004
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Just emailed Dr. Zamboni explaining where his theory is wrong, and how it fits into my theory.
Essentially for Multiple Sclerosis - tight junction leakiness (often exacerbated by reduced sheer stress such as in veinous insufficiency) -> reduced biotin, serotonin and dopamine -> reduced mylenation -> reduced signal strength (which is the neural signal for 'help i'm under attack') -> immune cells congregate at the site looking for pathogens. Another simple as pie explanation that complete explains the pathology and comorbidities of the disease using my framework.
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posted
Wow. That certainly fits with Thing Two's story.
quote:Originally posted by LetterRip: And for those who are interested here is the dime tour,
The core of the theory is that damage/dysfunction of the tight junctions of the blood brain barrier (and other tight junctions such as those surrounding innervation to organs) results in nutrients that are actively transported across the BBB 'leaking out' of the Interstitial Fluid (ISF) back to the blood. This includes many components needed for the synthesis of of key neurotransmitters (particularly L-DOPA/dopamine/epinephrine/norepinephrine the 'dopamine path' and melatonin/serotonin + creatine/adenosine path) mylenation (biotin) and protection/repair of oxidative damage (Glutathione). This results in a biosynthesis path deficiency which is often comorbid with a blood deficiency of the relevant nutrients. The pattern of and intensity of the damage (as well as timing) and degree of deficiency determines the particular neurological disease and pathology encountered.
For many neurological diseases the occurrence of oxidative damage is primarily during fetal development (hypoxia + low glutathione) although often with later developmental damage. Oxidative damage to the tight junctions of the barriers surrounding organ innervation is the reason for comorbid auto immune diseases - and general oxidative damage can result in other diseases comorbidites that will be normally distributed (so you will see seemingly random commordibity with a large number of congenital diseases). Certain events after birth can result in further nutrient deficiency and/or oxidative damage and/or other causes of increased leakiness (ie low blood pressure). Also the demands due to growth will exacerbate deficiencies.
The brain has a compensatory mechanism for low dopamine - cortisol - which tightens the junctions and reduces their leakiness in a global manner, it also stimulates tryptophan catabolism because dopamine path competes with tryptophan path for nutrients and dopamine is more important for survival. This catabolism of tryptophan results in reduction of serotonin production (leading to comorbid depression, anxiety, anger, sleep disorders and numerous other issues related to serotonin path deficiency and increased autoimmune response). The compensation mechanism can result in undamaged areas gaining superior ability (savants, heightened sense or senses - smell, touch, hearing) as these brain areas will have a relative excess neurotransmitter and other nutrient availability to normal.
The results of twin studies are primarily due to shared vs unshared placenta, not genetics (as is clear when we look at dichorionic studies versus monochorionic for the few times they have been done ie for schizophrenia).
if you'd read the doc that I shared with you - it matches drastically better with his story. I can account for his food tastes, I can account for why he had the temporary reprieve after anesthesia (I can even suggest which specific anaesthetics might have been used).
Ie this is what I posted in the other thread,
quote:Pete,
have you had a chance to read it yet? Those of you who I requested not to disclose are free to discuss it now.
Pete, if you look at the most recent version it explains why your son loves spicy foods (cucumin extends the life of dopamine); why you son had a spontaneous temporary recovery under anaesthesia (some anaesthetics cause a temporary cessation of dopamine consumption allowing your sons brain to build up to normal levels of dopamine and it's precursors); why anger and such are becoming worse (cortisol is the brains way to compensate for low dopamine - cortisol initiates catabolism of tryptophan since both tryptophan and dopamine require many of the same precursors and the brain has a greater dependence on dopamine path than serotonin path - thus for adequate dopamine the brain sacrifices serotonin production. Growth puts increase demand on the dopamine system and hence he has even lower serotonin levels and thus increased anger, depression, anxiety, and other symptoms that result from serotonin deficiency). Why your son was exceptionally intelligent before the sudden decline (the compensation that the brain does for oxidative damage to the tight junctions is a universal compensation(primarily cortisol) so if parts of the brain are undamaged they will end up with superior performance.) Unfortunately high intelligence or other gifts tends to mean that part of the brain is already being compensated for oxidative damage (hence why 'brains' tend to have poor coordination or poor social ability or both; or top athletes tend to have poor intelligence or poor social skills or both) and thus an exceptional individual takes less oxidative stress to push them over the edge and result in significant mental decline.
So please
1) read it - then your jaw will drop
2) contact me so we can create a regimen specifically tailored to him (will have to be okayed with your doctor but it can be done purely nutrition with common OTCs so shouldn't be an issue, unless you want to try stacking some of the non OTCs - which might or might not be necessary). No promise of a cure, but I'd be surprised if there isn't drastic significant improvement.
posted
Will read it with my wife this week if not tonight. Shared some of your earlier stuff with her, and we'd done a number of those things, and thought that your other recommendations sounded promising. Kind of in survival mode here with a new job, so please don't take my delayed response as lack of interest.
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posted
No problem at all Didn't realize you had a new job. Not trying to pester you, but your son was my inspiration for the whole thing, so just praying that it works for him as much as I hope it will.
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posted
Does the first page of the book say, "Dedicated to Thing Two."?
I have to admit to a healthy dose of skepticism but I am still excited and hopeful for you. I also hope this leads to improvement for Pete's son.
Posts: 3639 | Registered: Nov 2000
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You mean cumin? Yes, I put that in more than half of my concoctions ... no wonder T2 flips over it. His height has been stunted too, due I think to malnutrition; his younger brother is way taller than him now. He was always active and gregarious until the MMR.
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posted
The link says that curcumin is in turmeric, but I can't find any source that says that it's also in cumin... would be nice if it was, since giving turmeric-yellow stuff to a kid who loves to throw food is a recipe for --- colorful afternoon. Posts: 44193 | Registered: Jun 2001
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posted
Are you planning on making it available to non-Kindle folks? Like in PDF or hardcopy? My brother-in-law has two autistic kids, and I'd love to send him a copy of this.
Posts: 2066 | Registered: Jul 2005
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posted
Can you give a break down then of the foods/spices you'd recommend?
I hear about the tumeric/cucumin and anecdotally I can tell you that I've been slipping that into my son's oatmeal for a few years now. I don't even know if he has autism spectrum disorder but if so it's pretty mild and he's been improving dramatically as far as speech, coordination, and sociability. Perhaps this is one reason why. I'd been doing it for the anti-cancer benefits we've heard about but that's great if there are neurological benefits as well.
I understand that for many people the case is closed on the link between vaccines and neurological problems in children but the theory I'd seen put forth was that for some children at that age the blood brain barrier could trap mercury type substances and that it's set up such that for some kids the barrier could allow toxins in but not back out again. Have you seen anything like that? Can such damage be reversed?
Back to the original question. What other foods/spices/substances would you recommend to optimize neurological health?
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posted
yeah I'm doing a pdf version - realize that i've been pulling 20+ hour days for most days the past two to three weeks now trying to get this thing done and my sisters wedding was last night. The combo has left me a bit exhausted.
My short term goals are to get this available via the google bookstore, apple bookstore, and as epub and pdf asap.
Then my next goal is spit and polish for researchers to feel a bit more comfy with it.
As far as foods
Watermelon - glutathione - however, glutathione is often poorly absorbed so cysteine is often preferable NAC (N-acetyl-cysteine) and also the cofactor whose name i forget offhand are good. Vitamin K - pickles are an awesome source. B vitamin complex - B12, B6, folic acid. Vitamin D - sunshine is a good source. You will often find that individuals with these diseases are anemic - if so molasses is awesome - gingersnap cookies and black licorice are yummy sources. Vitamin C from citrus (Oranges, Tomatoes). Biotin - egg yolk but NOT egg white. The yolk is rich in biotin and the white has enzymes that destroy biotin - probably to deny predators who eat the egg whole the benefit of the biotin. Melatonin is a good supplement - a cofactor for the glutathione. Minerals - selenium and zinc and potassium.
It is pretty obvious to tell what I'm deficient in based on what I eat - ie I love chicken and tunafish - two of the best sources of selenium. I lova bannanas - potassium. Chocoholic - zinc and caffeine. Iron - molasses and gingersnaps.
When my mom was morning sick with my sister - she could only eat oranges, and after a B6 shot could eat anything she wanted for two days. Hereditary anemia was leading to low dopamine, so her body was only letting her eat foods that improved dopamine production.
Regarding vaccines - as I note in the book - if you are low on glutathione then i would expect oxidative damage from heavy metals to tight junctions. SO for instance a vaccine shot after a recent or current sickness followed by taking acetominophen (which detroys glutathione) would be a serious risk of oxidative damage.
I personally think that acetominophen should seriously be considered for removal from the market.
As to the trapping theory that sounds like BS, just straight up oxidative damage.
Also antibiotics are a serious risk - the flora in your gut can grow back unbalanced and leave you seriously vitamin deficient (K, melatonin, B12, B6, folic acid) - I'm pretty sure the US RDAs are based on the assumption of normal gut flora and absorption and could be drastically low if your gut flora aren't functioning normally or if you have absorption issues.
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posted
Note that in my view, probably 3 of the biggests factors leading to modern increases of chronic illness are
1) Increased usage of acetominophin 2) Increased usage of antibotics 3) switch from iron cookware to aluminium/Teflon
Regarding the discussion in the other thread on obesity - I think people have the causation wrong. We eat because we are deficient and not filling a needed deficiency - if you find a low quality source of a nutrient you need and it provides say 1/6 of your need of that nutrient - you might end up eating 6 helpings of it. We are a nation of obesity due to low micronutrient density of our foods.
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posted
Wow, just had another major insight Have to go file another provisional patent then I can explain it.
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posted
At this rate, I'm starting to think I should hold out for your book's sequel or at least a second edition. Posts: 3639 | Registered: Nov 2000
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